Diazepam action

Diazepam action

• A. Increases seratonin
• B. Decreases acetylcholine
• C. Increases GABA activity
• D. Blocks NMDA receptors

Answer: (C)

Diazepam works by boosting the brain’s main inhibitory signal, GABA, at the GABA-A receptor. It is a positive allosteric modulator, so it doesn’t add more GABA itself but makes GABA binding more effective and increases how often the chloride channel opens when GABA is present. This enhances chloride influx, hyperpolarizes neurons, and dampens excitability. This mechanism explains its anxiolytic, sedative, anticonvulsant, and muscle-relaxant effects. It does not act by increasing serotonin, reducing acetylcholine, or blocking NMDA receptors.

Diazepam works by boosting the brain’s main inhibitory signal, GABA, at the GABA-A receptor. It is a positive allosteric modulator, so it doesn’t add more GABA itself but makes GABA binding more effective and increases how often the chloride channel opens when GABA is present. This enhances chloride influx, hyperpolarizes neurons, and dampens excitability. This mechanism explains its anxiolytic, sedative, anticonvulsant, and muscle-relaxant effects. It does not act by increasing serotonin, reducing acetylcholine, or blocking NMDA receptors.